Background: The higher education institutions will achieve autonomy traversing the path of graded accreditation. The autonomy of higher education is linked with the quality of education and accreditation. Higher education institutions will not only achieve autonomy but will sustain it in ever-changing external and internal environments.

Purpose: The purpose is to design strategies for the sustenance of autonomy in higher education institutions.

Method: The paper is based on an exploratory qualitative study conducted during 2020. The research objectives emanate from the review of the literature and the experiences of the researcher. The research objective is further explored from the literature review to formulate the research questions.The population for the study constitutes the autonomous higher education institutions of the country including engineering, management, pharmacy, and polytechnic institutions.  The researcher selected a purposive sample to gather the information and views of the respondents. Respondents were selected from all over India, all types of institutions, and all levels of the institute. The researcher designed a comprehensive, concise, precise, and accurate structured and semi-structured research instrument based on the literature, experiences, and focus group discussion. This research instrument was validated on content and construct in a group of six persons working in the area of autonomy. Then it was prepared in the Google form which was validated by forty respondents. The respondents are principals, heads of departments, senior faculty members working in national-level institutes, higher education institutes, and technical institutions.The instrument was mailed to more than 8000 respondents out of which 954 respondents provided information. The information is provided by principals, deans, heads of departments, and senior faculty members. Secondary information is also used to fill up the gap to achieve the research objective. The information received from structured instruments is compiled using Microsoft Excel Sheet to calculate the weighted mean and percentage.

Results: The strategies for sustaining autonomy at central government, state government, regulatory body, institute, teacher, and student levels are evolved.

Conclusion: To reap the full potential of autonomy and its sustenance strategies at different levels of hierarchy need to be effectively implemented on continuous basis.